Ser661
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Home > Phosphorylation Site Page: > Ser661  -  PKCB (rat)

Site Information
QNEFAGFsYTNPEFV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448672

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 4 ) , peptide sequencing ( 4 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
endothelial-aorta ( 3 ) , SF9 ( 4 )

Upstream Regulation
Kinases, in vitro:
PKCB (rat) ( 4 )
Phosphatases, in vitro:
PPP1CA (rat) ( 4 ) , PPP2CB (human) ( 4 )
Treatments:
beta-amyloid_40 ( 3 )

Downstream Regulation
Effects of modification on PKCB:
protein conformation ( 2 )

References 

1

Lin G, Brownsey RW, Macleod KM (2014) Complex regulation of PKCβ2 and PDK-1/AKT by ROCK2 in diabetic heart. PLoS One 9, e86520
24466133   Curated Info

2

Leonard TA, et al. (2011) Crystal structure and allosteric activation of protein kinase C βII. Cell 144, 55-66
21215369   Curated Info

3

Gentile MT, et al. (2004) Mechanisms of soluble beta-amyloid impairment of endothelial function. J Biol Chem 279, 48135-42
15319431   Curated Info

4

Keranen LM, Dutil EM, Newton AC (1995) Protein kinase C is regulated in vivo by three functionally distinct phosphorylations. Curr Biol 5, 1394-1403
8749392   Curated Info