Ser661
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Home > Phosphorylation Site Page: > Ser661  -  PKCB (human)

Site Information
QNEFAGFsYTNPEFV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448672

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 4 ) , phospho-antibody ( 1 , 2 , 3 , 4 ) , western blotting ( 1 , 2 , 3 , 4 )
Disease tissue studied:
breast cancer ( 2 ) , leukemia ( 3 ) , acute myelogenous leukemia ( 3 ) , lymphoma ( 3 ) , pancreatic cancer ( 2 ) , pancreatic carcinoma ( 2 )
Relevant cell line - cell type - tissue:
21T (breast cell) ( 2 ) , 293 (epithelial) ( 4 ) , HEK293T (epithelial) ( 2 ) , MCF-7 (breast cell) ( 4 ) , mononuclear ( 3 ) , MV4-11 (macrophage) ( 3 ) , neutrophil-blood ( 1 ) , PANC-1 (pancreatic) ( 2 ) , THP1 (myeloid) ( 3 ) , U-937 (myeloid) ( 3 )

Upstream Regulation
Regulatory protein:
FPR1 (mouse) ( 1 ) , PHLPP (human) ( 2 ) , PHLPP2 (human) ( 2 )
Treatments:
fumonisin_B1 ( 4 ) , phorbol_ester ( 4 ) , PKC412 ( 3 ) , thymoquinone ( 1 )

Downstream Regulation
Effects of modification on PKCB:
intracellular localization ( 4 )

References 

1

Boudiaf K, et al. (2016) Thymoquinone strongly inhibits fMLF-induced neutrophil functions and exhibits anti-inflammatory properties in vivo. Biochem Pharmacol 104, 62-73
26774451   Curated Info

2

Qiao M, et al. (2010) Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis. Mol Cell 38, 512-23
20513427   Curated Info

3

Odgerel T, et al. (2008) The FLT3 inhibitor PKC412 exerts differential cell cycle effects on leukemic cells depending on the presence of FLT3 mutations. Oncogene 27, 3102-10
18071308   Curated Info

4

Kitatani K, Idkowiak-Baldys J, Hannun YA (2007) Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641. J Biol Chem 282, 20647-56
17504762   Curated Info