Ser661
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Home > Phosphorylation Site Page: > Ser661  -  PKCB (human)

Site Information
QNEFAGFsYTNPEFV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448672

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 3 ) , immunoprecipitation ( 5 ) , mutation of modification site ( 7 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 , 6 , 7 ) , western blotting ( 1 , 2 , 4 , 5 , 6 , 7 )
Disease tissue studied:
breast cancer ( 5 ) , leukemia ( 6 ) , acute myelogenous leukemia ( 6 ) , lymphoma ( 6 ) , pancreatic cancer ( 5 ) , pancreatic carcinoma ( 5 ) , fibrosarcoma of soft tissue ( 2 )
Relevant cell line - cell type - tissue:
21T (breast cell) ( 5 ) , 293 (epithelial) ( 7 ) , Calu-1 (squamous) ( 2 ) , epithelial ( 1 ) , GSCs (glial) ( 3 ) , GSCs (glial) [MLC1 (human), knockdown, Short hairpin RNAs (shRNAs)] ( 3 ) , HEK293T (epithelial) ( 5 ) , HT1080 (fibroblast) ( 2 ) , MCF-7 (breast cell) ( 7 ) , mononuclear ( 6 ) , MV4-11 (macrophage) ( 6 ) , neutrophil-blood ( 4 ) , PANC-1 (pancreatic) ( 5 ) , THP1 (myeloid) ( 6 ) , U-937 (myeloid) ( 6 )

Upstream Regulation
Regulatory protein:
DJ-1 (human) ( 1 ) , FPR1 (mouse) ( 4 ) , PHLPP (human) ( 5 ) , PHLPP2 (human) ( 5 )
Treatments:
fumonisin_B1 ( 7 ) , phorbol_ester ( 7 ) , PKC412 ( 6 ) , RSL3 ( 2 ) , TGF-beta ( 1 ) , thymoquinone ( 4 )

Downstream Regulation
Effects of modification on PKCB:
enzymatic activity, induced ( 1 ) , intracellular localization ( 7 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )

References 

1

Das F, et al. (2022) Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1α-dependent expression of collagen I (α2) during renal fibrosis. J Biol Chem 298, 102246
35835217   Curated Info

2

Chen X, et al. (2022) Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis. Autophagy, 1-21
35403545   Curated Info

3

Lattier JM, et al. (2020) Megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1) promotes glioblastoma cell invasion in the brain microenvironment. Oncogene
33040087   Curated Info

4

Boudiaf K, et al. (2016) Thymoquinone strongly inhibits fMLF-induced neutrophil functions and exhibits anti-inflammatory properties in vivo. Biochem Pharmacol 104, 62-73
26774451   Curated Info

5

Qiao M, et al. (2010) Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis. Mol Cell 38, 512-23
20513427   Curated Info

6

Odgerel T, et al. (2008) The FLT3 inhibitor PKC412 exerts differential cell cycle effects on leukemic cells depending on the presence of FLT3 mutations. Oncogene 27, 3102-10
18071308   Curated Info

7

Kitatani K, Idkowiak-Baldys J, Hannun YA (2007) Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641. J Biol Chem 282, 20647-56
17504762   Curated Info

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