Tyr141
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Home > Phosphorylation Site Page: > Tyr141  -  ADRB2 (human)

Site Information
AITSPFKyQSLLTKN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449832

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , mutation of modification site ( 2 ) , phosphoamino acid analysis ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
CHO (fibroblast) ( 2 )

Upstream Regulation
Treatments:
insulin ( 2 )

Downstream Regulation
Effects of modification on ADRB2:
activity, induced ( 2 )

References 

1

Cruse G, et al. (2010) Counterregulation of beta(2)-adrenoceptor function in human mast cells by stem cell factor. J Allergy Clin Immunol 125, 257-63.e1-5
19864009   Curated Info

2

Valiquette M, Parent S, Loisel TP, Bouvier M (1995) Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor. EMBO J 14, 5542-9
8521811   Curated Info