Tyr9
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Home > Phosphorylation Site Page: > Tyr9  -  PDK1 (rat)

Site Information
ARTTSQLyDAVPIQS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447696

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
kidney cancer ( 1 )
Relevant cell line - cell type - tissue:
mesangial-kidney ( 1 )

Upstream Regulation
Regulatory protein:
NOX4 (human) ( 1 ) , Src (rat) ( 1 )
Kinases, in vitro:
Src (rat) ( 1 )
Treatments:
angiotensin_2 ( 1 ) , H2O2 ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on PDK1:
enzymatic activity, induced ( 1 )
Effects of modification on biological processes:
cell adhesion, altered ( 1 ) , translation, altered ( 1 )

References 

1

Block K, et al. (2008) Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression. J Biol Chem 283, 24061-76
18559349   Curated Info