Ser724
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Home > Phosphorylation Site Page: > Ser724  -  ADD1 (rat)

Site Information
KKKFRTPsFLKKSKK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449829

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 )
Relevant cell line - cell type - tissue:
'neuron, hippocampal'-brain ( 1 ) , 293 (epithelial) ( 1 ) , erythrocyte-blood ( 1 ) , MDCK (epithelial) ( 1 )

Upstream Regulation
Kinases, in vitro:
PKCA (cow) ( 1 ) , PKCA (rat) ( 2 )
Treatments:
colforsin ( 1 ) , phorbol_ester ( 1 )

Downstream Regulation
Effects of modification on ADD1:
intracellular localization ( 1 , 2 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 1 )

References 

1

Matsuoka Y, Li X, Bennett V (1998) Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neurons. J Cell Biol 142, 485-97
9679146   Curated Info

2

Fowler L, Everitt J, Stevens JL, Jaken S (1998) Redistribution and enhanced protein kinase C-mediated phosphorylation of alpha- and gamma-adducin during renal tumor progression. Cell Growth Differ 9, 405-13
9607561   Curated Info