Lys6
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Home > Sumoylation Site Page: > Lys6  -  Huntingtin (human)

Site Information
__MAtLEkLMkAFEs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 8545504

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'neuron, striatal' ( 1 ) , HeLa (cervical) ( 1 )

Downstream Regulation
Effects of modification on Huntingtin:
intracellular localization ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
Huntington's disease ( 1 )

References 

1

Steffan JS, et al. (2004) SUMO modification of Huntingtin and Huntington's disease pathology. Science 304, 100-4
15064418   Curated Info

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