Thr222
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Home > Phosphorylation Site Page: > Thr222  -  C/EBP-alpha (rat)

Site Information
HLQPGHPtPPPtPVP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449824

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Disease tissue studied:
liver cancer ( 3 )
Relevant cell line - cell type - tissue:
3T3-L1 (fibroblast) ( 3 ) , AD293 (epithelial) ( 3 ) , H4IIe (hepatic) ( 3 ) , RAW 264.7 (macrophage) ( 1 , 2 )

Upstream Regulation
Regulatory protein:
GSK3A (human) ( 3 )
Treatments:
CHIR99021 ( 3 ) , insulin ( 3 )

Downstream Regulation
Effects of modification on C/EBP-alpha:
activity, inhibited ( 3 )
Effects of modification on biological processes:
transcription, altered ( 3 )

References 

1

Yan W, et al. (2016) Progranulin Controls Sepsis via C/EBPα-Regulated Il10 Transcription and Ubiquitin Ligase/Proteasome-Mediated Protein Degradation. J Immunol 197, 3393-3405
27619993   Curated Info

2

Kim H, et al. (2015) A novel crosstalk between TLR4- and NOD2-mediated signaling in the regulation of intestinal inflammation. Sci Rep 5, 12018
26153766   Curated Info

3

Liu HK, et al. (2006) Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226. BMC Mol Biol 7, 14
16600022   Curated Info

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