Ser177
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Home > Phosphorylation Site Page: > Ser177  -  CPEB (mouse)

Site Information
DtRPILDsRSSsPSD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 483983

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 2 ) , neuron-'brain, cerebellum' [transgenic] ( 2 )

Upstream Regulation
Kinases, in vitro:
AurA (human) ( 3 )
Treatments:
NMDA ( 3 )

Downstream Regulation
Effects of modification on biological processes:
cytoskeletal reorganization ( 2 ) , neural plasticity ( 2 ) , translation, induced ( 2 )

References 

1

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

2

McEvoy M, et al. (2007) Cytoplasmic polyadenylation element binding protein 1-mediated mRNA translation in Purkinje neurons is required for cerebellar long-term depression and motor coordination. J Neurosci 27, 6400-11
17567800   Curated Info

3

Huang YS, Jung MY, Sarkissian M, Richter JD (2002) N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses. EMBO J 21, 2139-48
11980711   Curated Info

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