Ser385
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Home > Phosphorylation Site Page: > Ser385  -  KCNJ8 (rat)

Site Information
NsLRKRNsMRRNNsM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 483976

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
PKACA (human) ( 3 ) , PKCA (human) ( 1 )

Downstream Regulation
Effects of modification on KCNJ8:
activity, induced ( 3 ) , activity, inhibited ( 1 )

References 

1

Shi Y, Cui N, Shi W, Jiang C (2008) A short motif in kir6.1 consisting of four phosphorylation repeats underlies the vascular KATP channel inhibition by protein kinase C. J Biol Chem 283, 2488-94
18048350   Curated Info

2

Shi Y, et al. (2007) PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by beta-adrenergic receptors. Am J Physiol Regul Integr Comp Physiol 293, R1205-14
17596331   Curated Info

3

Quinn KV, Giblin JP, Tinker A (2004) Multisite phosphorylation mechanism for protein kinase A activation of the smooth muscle ATP-sensitive K+ channel. Circ Res 94, 1359-66
15087422   Curated Info