Ser120
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Home > Phosphorylation Site Page: > Ser120  -  RPT6 (human)

Site Information
RVALRNDsYTLHKIL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 483970

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 3 ) , immunoprecipitation ( 3 ) , mass spectrometry ( 1 , 2 , 4 ) , mutation of modification site ( 3 , 5 ) , phospho-antibody ( 5 ) , western blotting ( 3 , 5 )
Relevant cell line - cell type - tissue:
'brain, striatum' ( 3 ) , 293 (epithelial) ( 5 ) , HeLa (cervical) ( 1 ) , Jurkat (T lymphocyte) ( 2 ) , K562 (erythroid) ( 4 ) , ST14A ( 3 )

Upstream Regulation
Regulatory protein:
Huntingtin (human) ( 3 )
Putative in vivo kinases:
PKACA (human) ( 3 , 5 )
Kinases, in vitro:
PKACA (human) ( 5 )
Treatments:
cAMP_analog ( 3 ) , CGS_21680 ( 3 ) , colforsin ( 5 ) , H-89 ( 3 , 5 ) , NKH_477 ( 3 )

Downstream Regulation
Effects of modification on RPT6:
activity, induced ( 3 , 5 ) , molecular association, regulation ( 3 )

References 

1

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

2

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

3

Lin JT, et al. (2013) Regulation of feedback between protein kinase A and the proteasome system worsens Huntington's disease. Mol Cell Biol 33, 1073-84
23275441   Curated Info

4

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

5

Zhang F, et al. (2007) Proteasome function is regulated by cyclic AMP-dependent protein kinase through phosphorylation of Rpt6. J Biol Chem 282, 22460-71
17565987   Curated Info

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