Ser355

Site Information
SVKTRPAsKKRKKEA SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 483969

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:	lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:	CHO-K1 (fibroblast) ( 1 ) , HEK293T (epithelial) ( 1 ) , HT-22 (neuron) ( 1 ) , NCI-H1299 (pulmonary) ( 1 )

Downstream Regulation
Effects of modification on VRK1:	enzymatic activity, inhibited ( 1 )
Effects of modification on biological processes:	apoptosis, altered ( 1 ) , cell cycle regulation ( 1 )

References
1	Park CH, et al. (2011) Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage-induced apoptosis. Mol Biol Cell 22, 1398-408 21346188 Curated Info