Ser156
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Home > Phosphorylation Site Page: > Ser156  -  MARCKS (rat)

Site Information
KRFsFKKsFkLsGFs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447787

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mass spectrometry ( 1 ) , phospho-antibody ( 2 , 3 , 4 , 5 ) , western blotting ( 2 , 3 )
Relevant cell line - cell type - tissue:
'brain, hippocampus' ( 2 ) , 'neuron, hippocampal'-brain ( 4 ) , adipose tissue ( 1 ) , artery-heart ( 5 ) , carotid artery ( 3 ) , lung ( 1 ) , NG108-15 (neuron) ( 5 ) , stomach ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKCA (rat) ( 4 )
Kinases, in vitro:
PKCA (rat) ( 4 , 5 , 6 )
Treatments:
5-HT ( 3 ) , bisindolylmaleimide ( 3 ) , calphostin_C ( 4 ) , endothelin ( 5 ) , glutamic acid ( 4 ) , ketanserin ( 3 ) , NMDA ( 4 ) , PAF ( 2 ) , PD98059 ( 4 ) , phorbol_ester ( 3 , 4 , 5 ) , TNF ( 5 )

References 

1

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

2

Moriguchi S, Shioda N, Yamamoto Y, Fukunaga K (2010) Platelet-activating factor-induced synaptic facilitation is associated with increased calcium/calmodulin-dependent protein kinase II, protein kinase C and extracellular signal-regulated kinase activities in the rat hippocampal CA1 region. Neuroscience 166, 1158-66
20074623   Curated Info

3

Peng YJ, et al. (2006) 5-HT evokes sensory long-term facilitation of rodent carotid body via activation of NADPH oxidase. J Physiol 576, 289-95
16887872   Curated Info

4

Ohmitsu M, Fukunaga K, Yamamoto H, Miyamoto E (1999) Phosphorylation of myristoylated alanine-rich protein kinase C substrate by mitogen-activated protein kinase in cultured rat hippocampal neurons following stimulation of glutamate receptors. J Biol Chem 274, 408-17
9867858   Curated Info

5

Yamamoto H, et al. (1998) The antibody specific for myristoylated alanine-rich C kinase substrate phosphorylated by protein kinase C: activation of protein kinase C in smooth muscle cells in human coronary arteries. Arch Biochem Biophys 359, 151-9
9808756   Curated Info

6

Heemskerk FM, Chen HC, Huang FL (1993) Protein kinase C phosphorylates Ser152, Ser156 and Ser163 but not Ser160 of MARCKS in rat brain. Biochem Biophys Res Commun 190, 236-41
8422248   Curated Info