Thr53

Site Information
IVADQtPtPtRFLKN SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 448225

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 ) , phospho-antibody ( 3 , 4 , 5 , 6 ) , western blotting ( 3 )
Disease tissue studied:	adrenal cancer ( 3 ) , pheochromocytoma ( 3 )
Relevant cell line - cell type - tissue:	'neuron, cerebellar granule'-brain ( 5 ) , adipose tissue ( 1 ) , kidney ( 1 ) , liver ( 1 , 2 ) , lung ( 1 ) , neuron-'brain, hippocampus' ( 6 ) , PC-12 (chromaffin) ( 3 , 4 , 6 ) , spleen ( 1 )

Upstream Regulation
Regulatory protein:	JNK3 (rat) ( 3 ) , MTPN (human) ( 4 )
Treatments:	colforsin ( 4 ) , H2O2 ( 3 ) , hypoxia ( 6 ) , ischemia ( 5 , 6 ) , ischemia/reperfusion ( 5 ) , NGF ( 3 , 4 ) , okadaic_acid ( 6 ) , taxol ( 3 ) , UV ( 3 )

References
1	Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876 22673903 Curated Info
2	Demirkan G, et al. (2011) Phosphoproteomic Profiling of In Vivo Signaling in Liver by the Mammalian Target of Rapamycin Complex 1 (mTORC1). PLoS One 6, e21729 21738781 Curated Info
3	Waetzig V, Herdegen T (2003) A single c-Jun N-terminal kinase isoform (JNK3-p54) is an effector in both neuronal differentiation and cell death. J Biol Chem 278, 567-72 12401814 Curated Info
4	Suzuki T, Yamakuni T, Hagiwara M, Ichinose H (2002) Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene. J Biol Chem 277, 40768-74 12196528 Curated Info
5	Hu BR, et al. (1999) Persistent phosphorylation of cyclic AMP responsive element-binding protein and activating transcription factor-2 transcription factors following transient cerebral ischemia in rat brain. Neuroscience 89, 437-52 10077326 Curated Info
6	Walton M, et al. (1998) ATF-2 phosphorylation in apoptotic neuronal death. Brain Res Mol Brain Res 63, 198-204 9838112 Curated Info
7	Livingstone C, Patel G, Jones N (1995) ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J 14, 1785-97 7737129 Curated Info