Thr183
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Home > Phosphorylation Site Page: > Thr183  -  JNK1 iso2 (human)

Site Information
AGTSFMMtPyVVTRY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447643

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 2 , 3 , 4 ) , western blotting ( 2 , 3 , 4 )
Disease tissue studied:
cervical cancer ( 4 ) , cervical squamous cell carcinoma ( 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 4 ) , JB6 RT101 (epidermal) ( 2 ) , KB (squamous) ( 4 ) , myocyte-heart ( 3 )

Upstream Regulation
Kinases, in vitro:
MKK7 (human) ( 4 )
Treatments:
anisomycin ( 4 ) , IL-1a ( 4 ) , osmotic_stress ( 4 ) , thrombin ( 3 ) , TNF ( 4 ) , UV ( 4 )

References 

1

Chaturvedi A, et al. (2011) Endocytosed BCRs sequentially regulate MAPK and Akt signaling pathways from intracellular compartments. Nat Immunol 12, 1119-26
21964606   Curated Info

2

Lu C, et al. (2006) Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3. Mol Cell 23, 121-32
16818236   Curated Info

3

Tanabe K, et al. (2005) Midazolam suppresses thrombin-induced heat shock protein 27 phosphorylation through inhibition of p38 mitogen-activated protein kinase in cardiac myocytes. J Cell Biochem 96, 56-64
16052527   Curated Info

4

Fleming Y, et al. (2000) Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. Biochem J 352 Pt 1, 145-54
11062067   Curated Info