Ser9
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Site Information
SGRPRTTsFAESCKP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449111

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 78 ) , immunoassay ( 3 ) , immunoprecipitation ( 8 , 10 , 20 , 31 , 77 ) , mass spectrometry (in vitro) ( 10 ) , mutation of modification site ( 5 , 10 , 38 , 48 , 59 , 65 , 73 , 75 , 76 , 77 , 78 ) , phospho-antibody ( 3 , 4 , 5 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 51 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 ) , western blotting ( 3 , 4 , 5 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 46 , 47 , 48 , 49 , 51 , 56 , 57 , 58 , 61 , 63 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 75 , 76 , 77 )
Disease tissue studied:
Alzheimer's disease ( 23 ) , adrenal cancer ( 8 , 15 , 58 ) , pheochromocytoma ( 8 , 15 , 58 ) , brain cancer ( 19 ) , glioma ( 19 ) , liver cancer ( 48 ) , neuroblastoma ( 58 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 3 , 24 ) , 'brain, hippocampus' ( 7 , 15 , 16 , 21 , 31 ) , 'brain, striatum' ( 24 ) , 'muscle, skeletal' ( 10 , 12 , 22 , 34 , 39 , 41 , 51 , 54 , 62 , 68 , 72 ) , 'neuron, bipolar' ( 63 ) , 'neuron, cerebellar granule'-brain ( 11 , 57 , 59 ) , 'neuron, cortical'-brain ( 36 , 65 , 66 ) , 'neuron, hippocampal'-brain ( 9 ) , 293 (epithelial) ( 59 , 78 ) , 3T3 (fibroblast) ( 70 ) , 3T3-L1 (fibroblast) ( 25 , 48 ) , A7r5 ('muscle, smooth') ( 67 ) , AD293 (epithelial) ( 48 ) , BHK-21 (fibroblast) ( 71 ) , brain ( 23 ) , C2C12 (myoblast) ( 28 , 33 ) , C6 (glial) ( 19 ) , CHO-K1 (fibroblast) ( 69 ) , fibroblast ( 49 ) , GLUTag ( 64 ) , H4IIe (hepatic) ( 48 ) , H9c2 (myoblast) ( 17 ) , heart ( 17 , 42 , 61 ) , HEK293T (epithelial) ( 10 ) , IEC-18 (epithelial) ( 18 ) , L6 (myoblast) ( 29 , 43 ) , liver ( 27 , 44 , 53 ) , mesangial ( 38 ) , muscle ( 47 ) , myocyte ( 55 ) , myocyte-heart ( 13 , 17 , 33 , 35 , 46 , 76 ) , neuron-'brain, cerebellum' ( 26 , 58 , 75 ) , neuron-'brain, cerebral cortex' ( 20 ) , neuron-'brain, hippocampus' ( 5 , 56 ) , PC-12 (chromaffin) ( 8 , 15 , 58 , 74 , 77 ) , RAEC (endothelial) ( 37 ) , Rat1 (fibroblast) ( 73 ) , retinal ganglion ( 60 ) , RPE-J (epithelial) ( 14 ) , SH-SY5Y (neural crest) ( 58 , 77 ) , skin ( 4 ) , spinal cord ( 40 )

Upstream Regulation
Regulatory protein:
ADCY6 (mouse) ( 32 ) , CDC42 (human) ( 5 ) , FAK (rat) ( 43 ) , GSK3A (rat) ( 36 ) , GSK3B (rat) ( 36 ) , ITGB1 (rat) ( 35 )
Putative in vivo kinases:
Akt1 (rat) ( 59 ) , CAMK2B (rat) ( 20 ) , PKACA (rat) ( 64 , 71 , 75 )
Kinases, in vitro:
CAMK2B (human) ( 20 ) , GSK3B (rabbit) ( 78 ) , p70S6K (rat) ( 79 ) , PKACA (human) ( 75 ) , PKG1 (human) ( 50 )
Treatments:
2-deoxyglucose ( 67 ) , 5-thio-glucose ( 67 ) , 6-OHDA ( 58 ) , acadesine ( 28 , 39 ) , action_potential ( 11 ) , AG1478 ( 18 ) , Akt-I-1,2 ( 11 ) , Akt_inhibitor_X ( 11 ) , anti-TNFalpha ( 68 ) , API-2 ( 29 ) , APV ( 11 ) , aripiprazole ( 8 ) , BDNF ( 24 , 56 , 63 , 65 ) , BIO ( 40 ) , blood pressure ( 55 ) , BW373U86 ( 61 ) , cAMP_analog ( 64 , 75 ) , cGMP_analog ( 50 , 64 ) , CHIR99021 ( 48 ) , chronic stress ( 7 ) , clozapine ( 8 ) , CNQX ( 11 ) , colchicine ( 57 ) , colforsin ( 64 , 71 , 75 ) , CT98014 ( 34 ) , culturing_of_cells ( 36 ) , depolarization ( 20 ) , dexamethasone ( 51 ) , endothelin ( 76 ) , ethanol ( 44 ) , exercise ( 41 , 51 , 54 , 72 ) , fasting ( 22 , 47 ) , fibronectin ( 49 ) , fluoxetine ( 7 ) , folic acid ( 31 ) , GLP-2 ( 71 ) , glucose ( 17 , 67 ) , Go_6983 ( 73 ) , GSK-3_inhibitor_I ( 36 ) , GSK-3_inhibitor_VII ( 36 ) , H-89 ( 71 , 75 ) , H-CHO ( 45 ) , haloperidol ( 8 ) , high-fat diet ( 21 ) , homocysteine ( 31 ) , hypoxia ( 9 , 25 , 37 , 67 , 74 ) , hypoxia/reoxygenation ( 46 ) , IGF-1 ( 13 , 20 , 38 , 75 ) , IGF-2 ( 16 ) , indirubin ( 28 ) , insulin ( 12 , 22 , 26 , 27 , 29 , 30 , 34 , 39 , 43 , 47 , 48 , 51 , 52 , 60 , 69 , 70 , 72 , 73 , 77 ) , irbesartan ( 27 ) , ischemia ( 21 ) , ischemia/reperfusion ( 61 ) , isoproterenol ( 32 , 35 ) , KCl ( 26 ) , kenpaullone ( 26 ) , KN-62 ( 20 ) , learning ( 16 ) , leptin ( 53 ) , lithium ( 26 , 30 , 33 , 36 , 57 , 69 , 77 ) , LY294002 ( 14 , 18 , 19 , 20 , 24 , 60 , 65 , 66 , 67 , 69 , 71 , 73 , 76 ) , MCAO/R ( 3 ) , morphine ( 40 , 61 ) , mPKI ( 75 ) , MRS1334 ( 42 ) , muscle atrophy ( 62 ) , muscle contraction ( 12 , 22 ) , Myristoleic acid ( 4 ) , neurotrophin-3 ( 56 ) , NGF ( 56 ) , okadaic_acid ( 23 ) , OSU-03012 ( 14 ) , PCP ( 24 ) , PD98059 ( 17 , 20 , 24 , 65 , 75 ) , phenylephrine ( 13 , 52 , 73 ) , phorbol_ester ( 69 ) , piclidenoson ( 42 ) , PIK90 ( 29 ) , pioglitazone ( 3 ) , PKI ( 20 ) , pleiotrophin ( 33 ) , PP242 ( 29 ) , rapamycin ( 29 , 42 , 54 , 61 ) , reelin ( 66 ) , rosiglitazone ( 70 ) , SB216763 ( 40 ) , seliciclib ( 40 ) , sepsis ( 68 ) , serum ( 69 ) , serum_withdrawal ( 65 ) , sildenafil ( 55 ) , siRNA ( 43 ) , SL327 ( 65 ) , SP600125 ( 46 ) , STO-609 ( 20 ) , streptozotocin ( 21 ) , tamoxifen ( 19 ) , TeTx ( 63 ) , thapsigargin ( 58 ) , thrombin ( 14 ) , tungstate ( 45 ) , tunicamycin ( 58 ) , U0126 ( 20 , 52 ) , V-150 ( 46 ) , valproic_acid ( 26 ) , vitamin_B12 ( 31 ) , wortmannin ( 20 , 35 , 42 , 56 , 61 , 72 , 74 , 76 ) , wounding ( 18 )

Downstream Regulation
Effects of modification on GSK3B:
activity, inhibited ( 73 , 78 ) , enzymatic activity, inhibited ( 5 , 19 , 26 , 76 ) , intracellular localization ( 17 , 18 ) , molecular association, regulation ( 59 ) , phosphorylation ( 5 ) , protein stabilization ( 14 )
Effects of modification on biological processes:
apoptosis, altered ( 20 , 38 ) , apoptosis, inhibited ( 3 , 19 , 75 ) , autophagy, induced ( 4 ) , cell cycle regulation ( 4 ) , cell growth, altered ( 76 ) , cell growth, induced ( 4 , 14 ) , cell motility, induced ( 18 ) , cytoskeletal reorganization ( 5 ) , signaling pathway regulation ( 13 ) , transcription, altered ( 76 )
Induce interaction with:
14-3-3 beta (rat) ( 59 )

Disease / Diagnostics Relevance
Relevant diseases:
diabetes mellitus ( 21 ) , type 2 diabetes ( 21 )

References 

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25

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26

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27

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34

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47

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48

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50

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51

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