Ser659
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.5
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser659  -  ACSS2 (human)

Site Information
PGLPKTRsGKIMRRV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 83970101

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , immunoprecipitation ( 4 ) , mass spectrometry ( 4 ) , mutation of modification site ( 1 , 4 ) , phospho-antibody ( 2 , 4 ) , western blotting ( 4 )
Disease tissue studied:
brain cancer ( 4 ) , glioblastoma ( 4 ) , glioma ( 4 ) , lung cancer ( 4 ) , non-small cell lung cancer ( 4 ) , pancreatic cancer ( 4 ) , pancreatic carcinoma ( 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AMPKA1 (human) ( 4 )
Treatments:
glucose_starvation ( 4 )

Downstream Regulation
Effects of modification on ACSS2:
intracellular localization ( 1 , 3 , 4 ) , molecular association, regulation ( 4 )
Effects of modification on biological processes:
autophagy, induced ( 4 ) , transcription, induced ( 4 )
Induce interaction with:
KPNA5 (human) ( 4 )

Disease / Diagnostics Relevance
Relevant diseases:
glioma ( 4 ) , non-small cell lung cancer ( 2 )

References 

1

Chen N, et al. (2024) ACSS2 controls PPARĪ³ activity homeostasis to potentiate adipose-tissue plasticity. Cell Death Differ
38332049   Curated Info

2

Yang X, et al. (2019) Prognostic Impact of Metabolism Reprogramming Markers Acetyl-CoA Synthetase 2 Phosphorylation and Ketohexokinase-A Expression in Non-Small-Cell Lung Carcinoma. Front Oncol 9, 1123
31750240   Curated Info

3

Li X, Qian X, Lu Z (2017) Local histone acetylation by ACSS2 promotes gene transcription for lysosomal biogenesis and autophagy. Autophagy 13, 1790-1791
28820290   Curated Info

4

Li X, et al. (2017) Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. Mol Cell 66, 684-697.e9
28552616   Curated Info