Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Phosphorylation Site Page:
Ser34 - RhoGDI alpha (rat)

Site Information
YkPPAQKsIQEIQEL   SwissProt Entrez-Gene
Predicted information:  Scansite
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 467490

In vivo Characterization
Methods used to characterize site in vivo: mass spectrometry (1), mutation of modification site (3), phospho-antibody (2, 3), western blotting (2, 3)
Disease tissue studied: adrenal cancer (3), pheochromocytoma (3)
Relevant cell line - cell type - tissue: 'brain, brainstem' (1), 'brain, cerebellum' (1), 'brain, cerebral cortex' (1), adipose tissue (1), fibroblast-embryo (2), intestine (1), kidney (1), liver (1), lung (1), muscle (1), pancreas (1), PC-12 (chromaffin) (3), spleen (1), stomach (1), testis (1), thymus (1)

Controlled by
Putative in vivo kinases: PAK2 (human) (3)
Kinases, in vitro: PAK2 (human) (3)
Treatments: U73122 (2)

Downstream Regulation
Effects of modification on RhoGDI alpha: molecular association, regulation (3)
Effects of modification on biological processes: cell growth, altered (3)
Inhibit interaction with: CDC42 iso1 (human) (3), RAC1 (rat) (3)



Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info


Dovas A, et al. (2010) Serine 34 phosphorylation of rho guanine dissociation inhibitor (RhoGDIalpha) links signaling from conventional protein kinase C to RhoGTPase in cell adhesion. J Biol Chem 285, 23296-308
20472934   Curated Info


Shin EY, et al. (2009) Phosphorylation of RhoGDI1 by p21-activated kinase 2 mediates basic fibroblast growth factor-stimulated neurite outgrowth in PC12 cells. Biochem Biophys Res Commun 379, 384-9
19103160   Curated Info

Home  |  Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2017 Cell Signaling Technology, Inc.