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Site Information |
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FTSTEPQyQPGENL_ SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 448235 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Regulatory protein: | |
Putative in vivo kinases: | |
Kinases, in vitro: | |
Putative upstream phosphatases: | |
Phosphatases, in vitro: | |
Treatments: |
Downstream Regulation | |
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Effects of modification on Src: | |
Effects of modification on biological processes: | |
Induce interaction with: | |
Inhibit interaction with: |
References | |
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Chitadze L, et al. (2024) Src-NADH dehydrogenase subunit 2 complex and recognition memory of imprinting in domestic chicks. PLoS One 19, e0297166
38285689 Curated Info |
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Meparishvili M, et al. (2021) Src and Memory: A Study of Filial Imprinting and Predispositions in the Domestic Chick. Front Physiol 12, 736999
34616310 Curated Info |
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Levinson NM, Seeliger MA, Cole PA, Kuriyan J (2008) Structural basis for the recognition of c-Src by its inactivator Csk. Cell 134, 124-34
18614016 Curated Info |
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Vielreicher M, et al. (2007) Dynamic interaction between Src and C-terminal Src kinase in integrin alphaIIbbeta3-mediated signaling to the cytoskeleton. J Biol Chem 282, 33623-31
17855352 Curated Info |
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Giannoni E, et al. (2005) Intracellular reactive oxygen species activate Src tyrosine kinase during cell adhesion and anchorage-dependent cell growth. Mol Cell Biol 25, 6391-403
16024778 Curated Info |
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Akagi T, Murata K, Shishido T, Hanafusa H (2002) v-Crk activates the phosphoinositide 3-kinase/AKT pathway by utilizing focal adhesion kinase and H-Ras. Mol Cell Biol 22, 7015-23
12242282 Curated Info |
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Cary LA, Klinghoffer RA, Sachsenmaier C, Cooper JA (2002) SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading. Mol Cell Biol 22, 2427-40
11909938 Curated Info |
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Zheng XM, Shalloway D (2001) Two mechanisms activate PTPalpha during mitosis. EMBO J 20, 6037-49
11689444 Curated Info |
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Zheng XM, Resnick RJ, Shalloway D (2000) A phosphotyrosine displacement mechanism for activation of Src by PTPalpha. EMBO J 19, 964-78
10698938 Curated Info |
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Zang Q, et al. (1997) Association between v-Src and protein kinase C delta in v-Src-transformed fibroblasts. J Biol Chem 272, 13275-80
9148947 Curated Info |
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Superti-Furga G, et al. (1993) Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src. EMBO J 12, 2625-34
7687537 Curated Info |
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Bagrodia S, Taylor SJ, Shalloway D (1993) Myristylation is required for Tyr-527 dephosphorylation and activation of pp60c-src in mitosis. Mol Cell Biol 13, 1464-70
7680096 Curated Info |
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Shenoy S, et al. (1992) Role of p34cdc2-mediated phosphorylations in two-step activation of pp60c-src during mitosis. Proc Natl Acad Sci U S A 89, 7237-41
1379736 Curated Info |
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Thomas JE, Soriano P, Brugge JS (1991) Phosphorylation of c-Src on tyrosine 527 by another protein tyrosine kinase. Science 254, 568-71
1719633 Curated Info |
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Nada S, et al. (1991) Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src. Nature 351, 69-72
1709258 Curated Info |
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Yaciuk P, Choi JK, Shalloway D (1989) Mutation of amino acids in pp60c-src that are phosphorylated by protein kinases C and A. Mol Cell Biol 9, 2453-63
2474754 Curated Info |
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Piwnica-Worms H, et al. (1987) Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src. Cell 49, 75-82
3103926 Curated Info |
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Kmiecik TE, Shalloway D (1987) Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation. Cell 49, 65-73
3103925 Curated Info |