Tyr679

Site Information
FGMSRDIySTDyyRV SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 449759

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 4 ) , phospho-antibody ( 4 )
Disease tissue studied:	adrenal cancer ( 1 , 2 ) , pheochromocytoma ( 1 , 2 )
Relevant cell line - cell type - tissue:	'neuron, cortical'-brain ( 4 ) , COS (fibroblast) ( 4 ) , PC-12 (chromaffin) ( 1 , 2 , 3 , 4 )

Upstream Regulation
Treatments:	neurotrophin-3 ( 4 ) , NGF ( 4 )

References
1	Guo A (2008) CST Curation Set: 5202; Year: 2008; Biosample/Treatment: cell line, PC-12/NGF; Disease: pheochromocytoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
2	Guo A (2008) CST Curation Set: 5203; Year: 2008; Biosample/Treatment: cell line, PC-12/NGF; Disease: pheochromocytoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
3	Stokes M (2007) CST Curation Set: 3524; Year: 2007; Biosample/Treatment: cell line, PC-12/NGF; Disease: pheochromocytoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info
4	Liu HY, Meakin SO (2002) ShcB and ShcC activation by the Trk family of receptor tyrosine kinases. J Biol Chem 277, 26046-56 12006576 Curated Info