Ser390
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Home > Phosphorylation Site Page: > Ser390  -  ELK1 (mouse)

Site Information
LsPIAPRsPAKLSFQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449757

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 6 ) , [32P] bio-synthetic labeling ( 6 ) , mutation of modification site ( 3 , 4 , 5 , 6 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 ) , phosphopeptide mapping ( 6 ) , western blotting ( 1 , 2 , 4 , 5 )
Disease tissue studied:
leukemia ( 1 ) , acute myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:
'B lymphocyte, precursor' ( 4 ) , 'brain, striatum' ( 5 ) , 3T3 (fibroblast) ( 6 ) , B lymphocyte ( 4 ) , macrophage-bone marrow ( 2 ) , MEF (fibroblast) [ELK1 (mouse), homozygous knockout] ( 3 ) , MEF (fibroblast) ( 3 ) , THP1 (myeloid) ( 1 )

Upstream Regulation
Regulatory protein:
Cot (human) ( 2 ) , NFkB-p105 (human) ( 2 )
Kinases, in vitro:
ERK1 (mouse) ( 6 ) , ERK2 (human) ( 3 )
Treatments:
asprosin ( 1 ) , EGF ( 6 ) , LPS ( 2 ) , PD0325901 ( 2 ) , phorbol_ester ( 3 ) , serum ( 6 )

Downstream Regulation
Effects of modification on ELK1:
intracellular localization ( 5 ) , molecular association, regulation ( 3 )
Effects of modification on biological processes:
cell differentiation, altered ( 5 ) , cell growth, altered ( 4 ) , cytoskeletal reorganization ( 5 ) , transcription, altered ( 6 ) , transcription, induced ( 2 , 3 , 4 , 5 )
Induce interaction with:
DNA ( 6 ) , MED16 (mouse) ( 3 ) , MED23 (mouse) ( 3 ) , Trap100 (mouse) ( 3 )

References 

1

Zou J, et al. (2022) Asprosin inhibits macrophage lipid accumulation and reduces atherosclerotic burden by up-regulating ABCA1 and ABCG1 expression via the p38/Elk-1 pathway. J Transl Med 20, 337
35902881   Curated Info

2

Blair L, et al. (2022) TPL-2 Inhibits IFN-β Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages. J Immunol 208, 941-954
35082159   Curated Info

3

Mylona A, et al. (2016) Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation. Science 354, 233-237
27738173   Curated Info

4

Yasuda T, et al. (2008) Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity 28, 499-508
18356083   Curated Info

5

Lavaur J, et al. (2007) A TAT-DEF-Elk-1 peptide regulates the cytonuclear trafficking of Elk-1 and controls cytoskeleton dynamics. J Neurosci 27, 14448-58
18160653   Curated Info

6

Gille H, et al. (1995) ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J 14, 951-62
7889942   Curated Info