Ser64
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Home > Phosphorylation Site Page: > Ser64  -  WRAP53 (human)

Site Information
PVAGSAVsQELREGD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 482238

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 , 4 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ATM (human) ( 1 )
Treatments:
ionizing_radiation ( 1 ) , KU-55933 ( 1 ) , NU7441 ( 1 ) , VE-821 ( 1 )

Downstream Regulation
Effects of modification on WRAP53:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
DNA repair, induced ( 1 )
Induce interaction with:
H2AX (human) ( 1 )

References 

1

Coucoravas C, et al. (2017) Phosphorylation of the Cajal body protein WRAP53β by ATM promotes its involvement in the DNA damage response. RNA Biol 14, 804-813
27715493   Curated Info

2

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

3

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

4

Matsuoka S, et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-6
17525332   Curated Info