Ser776
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Home > Phosphorylation Site Page: > Ser776  -  PNPT1 (human)

Site Information
IVMGEPIsQSSSNsQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 482067

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 ) , breast adenocarcinoma ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
DNAPK (human) ( 1 )
Kinases, in vitro:
DNAPK (human) ( 1 )
Treatments:
ionizing_radiation ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on PNPT1:
enzymatic activity, inhibited ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , RNA stability, induced ( 1 )

References 

1

Yu YL, et al. (2012) Nuclear EGFR Suppresses Ribonuclease Activity of Polynucleotide Phosphorylase through DNAPK-mediated Phosphorylation at Serine 776. J Biol Chem 287, 31015-26
22815474   Curated Info

2

Matsuoka S, et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-6
17525332   Curated Info