Ser2049

Site Information
KDIELVMsQANVsRA SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 481869
Available spectra: 1 CST

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 3 , 4 , 5 , 6 )
Disease tissue studied:	HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , cervical cancer ( 5 ) , cervical adenocarcinoma ( 5 ) , lung cancer ( 3 , 4 ) , non-small cell lung cancer ( 3 , 4 ) , non-small cell lung adenocarcinoma ( 3 , 4 ) , non-small cell large cell lung carcinoma ( 3 )
Relevant cell line - cell type - tissue:	breast ( 1 ) , Cal-12T (pulmonary) ( 4 ) , HCC44 (pulmonary) ( 4 ) , HEK293T (epithelial) ( 6 ) , HeLa S3 (cervical) ( 5 ) , lung ( 3 , 4 ) , NCI-H1299 (pulmonary) ( 3 ) , NCI-H1437 (pulmonary) ( 4 ) , NCI-H1666 (pulmonary) ( 4 ) , NCI-H1734 (pulmonary) ( 3 ) , NCI-H1944 (pulmonary) ( 3 ) , NCI-H2405 (pulmonary) ( 4 ) , NCI-H358 (pulmonary) ( 3 ) , NCI-H460 (pulmonary) ( 3 )

Upstream Regulation
Treatments:	nocodazole ( 5 )

References
1	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
2	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
3	Rikova K, Hall B (2013) CST Curation Set: 20737, 21164, 30161, 30162, 30163; Year: 2013; Biosample/Treatment: cell line, H1299, H1944, H358, H1734, H460; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P Curated Info
4	Rikova K, Hall B (2013) CST Curation Set: 20741, 21168, 30173, 30174, 30175; Year: 2013; Biosample/Treatment: cell line, H1666, CAL-12T, H2405, HCC44, H1437; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P Curated Info
5	Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3 20068231 Curated Info
6	Matsuoka S, et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-6 17525332 Curated Info