Thr373
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Home > Phosphorylation Site Page: > Thr373  -  ATM (human)

Site Information
IsQSyTttQRESSDy   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 481860

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on ATM:
enzymatic activity, inhibited ( 1 ) , protein conformation ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , cell cycle regulation ( 1 )

References 

1

Zhou Y, et al. (2017) Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM. Mol Cell 65, 91-104
27939942   Curated Info

2

Matsuoka S, et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-6
17525332   Curated Info