Ser85
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Home > Phosphorylation Site Page: > Ser85  -  ATM (human)

Site Information
AkPNVsAstQASRQK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 481858

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 , 4 , 5 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
ionizing_radiation ( 2 )

Downstream Regulation
Effects of modification on ATM:
enzymatic activity, inhibited ( 1 ) , molecular association, regulation ( 1 ) , protein conformation ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , cell cycle regulation ( 1 )
Inhibit interaction with:
MRE11A (human) ( 1 ) , NBS1 (human) ( 1 )

References 

1

Zhou Y, et al. (2017) Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM. Mol Cell 65, 91-104
27939942   Curated Info

2

Lee HJ, et al. (2015) Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Res 25, 225-36
25601159   Curated Info

3

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

4

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

5

Matsuoka S, et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-6
17525332   Curated Info