Ser246
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Home > Phosphorylation Site Page: > Ser246  -  ADRB2 (human)

Site Information
RFHVQNLsQVEQDGR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 481741
Available spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 5 , 8 , 9 , 10 , 11 )
Disease tissue studied:
breast cancer ( 5 ) , lung cancer ( 1 , 2 , 3 , 5 ) , non-small cell lung cancer ( 2 , 3 , 5 ) , non-small cell lung adenocarcinoma ( 2 , 3 ) , non-small cell large cell lung carcinoma ( 2 ) , small-cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) [AT1 (human), transfection, AT1R stable transfected HEK293] ( 9 ) , 293T (epithelial) ( 11 ) , BT-20 (breast cell) ( 5 ) , BT-549 (breast cell) ( 5 ) , Cal-12T (pulmonary) ( 3 ) , DMS53 (pulmonary) ( 1 ) , H2009 (pulmonary) ( 5 ) , H2887 (pulmonary) ( 5 ) , HCC1359 (pulmonary) ( 5 ) , HCC2279 (pulmonary) ( 5 ) , HCC4006 (pulmonary) ( 5 ) , HCC44 (pulmonary) ( 3 ) , HeLa (cervical) ( 8 ) , lung ( 1 , 2 , 3 ) , MDA-MB-231 (breast cell) ( 5 ) , MDA-MB-468 (breast cell) ( 5 ) , NCI-H1299 (pulmonary) ( 2 ) , NCI-H1437 (pulmonary) ( 3 ) , NCI-H1568 (pulmonary) ( 5 ) , NCI-H1666 (pulmonary) ( 3 ) , NCI-H1734 (pulmonary) ( 2 ) , NCI-H1944 (pulmonary) ( 2 ) , NCI-H2172 (pulmonary) ( 5 ) , NCI-H2405 (pulmonary) ( 3 ) , NCI-H358 (pulmonary) ( 2 ) , NCI-H446 (pulmonary) ( 1 ) , NCI-H460 (pulmonary) ( 2 ) , NCI-H526 (pulmonary) ( 1 ) , NCI-H647 (pulmonary) ( 5 ) , NCI-H69 (pulmonary) ( 1 ) , NCI-H82 (pulmonary) ( 1 ) , TERT20 ('stem, mesenchymal') ( 10 )

Upstream Regulation
Treatments:
angiotensin_2 ( 9 )

References 

1

Rikova K, Hall B (2013) CST Curation Set: 20735, 21162, 30155, 30156, 30157; Year: 2013; Biosample/Treatment: cell line, DMS53, H526, H69, H82, H446; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P
Curated Info

2

Rikova K, Hall B (2013) CST Curation Set: 20737, 21164, 30161, 30162, 30163; Year: 2013; Biosample/Treatment: cell line, H1299, H1944, H358, H1734, H460; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P
Curated Info

3

Rikova K, Hall B (2013) CST Curation Set: 20741, 21168, 30173, 30174, 30175; Year: 2013; Biosample/Treatment: cell line, H1666, CAL-12T, H2405, HCC44, H1437; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P
Curated Info

4

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

5

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

6

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

7

Nobles KN, et al. (2011) Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Sci Signal 4, ra51
21868357   Curated Info

8

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

9

Christensen GL, et al. (2010) Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists. Mol Cell Proteomics 9, 1540-53
20363803   Curated Info

10

Thingholm TE, et al. (2008) TiO2-Based Phosphoproteomic Analysis of the Plasma Membrane and the Effects of Phosphatase Inhibitor Treatment. J Proteome Res 7, 3304-3313
18578522   Curated Info

11

Matsuoka S, et al. (2007) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-6
17525332   Curated Info