Lys471

Site Information
kVGGRYLkGDHAGVL SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 8102207

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 4 , 5 ) , mutation of modification site ( 4 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 4 ) , HEK293T (epithelial) ( 4 ) , HEp-2 (squamous) ( 1 ) , Jurkat (T lymphocyte) ( 1 ) , U2OS (bone cell) ( 2 , 5 )

Downstream Regulation
Effects of modification on biological processes:	cytoskeletal reorganization ( 4 )

References
1	Akimov V, et al. (2018) UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites. Nat Struct Mol Biol 25, 631-640 29967540 Curated Info
2	Halim VA, et al. (2018) Doxorubicin-induced DNA Damage Causes Extensive Ubiquitination of Ribosomal Proteins Associated with a Decrease in Protein Translation. Mol Cell Proteomics 29438997 Curated Info
3	Lumpkin RJ, et al. (2017) Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. Nat Commun 8, 1171 29079793 Curated Info
4	Lin S, et al. (2016) Monoubiquitination Inhibits the Actin Bundling Activity of Fascin. J Biol Chem 291, 27323-27333 27879315 Curated Info
5	Povlsen LK, et al. (2012) Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Nat Cell Biol 14, 1089-98 23000965 Curated Info