Ser98
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Home > Phosphorylation Site Page: > Ser98  -  BIM (human)

Site Information
RSssGyFsFDTDRsP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 8080218

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AurA (human) ( 1 )
Kinases, in vitro:
AurA (human) ( 1 )
Putative upstream phosphatases:
PPP2CA (human) ( 1 )
Treatments:
BI-D1870 ( 1 ) , C2-ceramide ( 1 ) , MLN8054 ( 1 ) , nocodazole ( 1 ) , okadaic_acid ( 1 ) , RO-3306 ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on BIM:
molecular association, regulation ( 1 ) , protein degradation ( 1 ) , ubiquitination ( 1 )
Induce interaction with:
BTRC (human) ( 1 )

References 

1

Moustafa-Kamal M, et al. (2013) BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by ╬▓TrCP1. Cell Death Differ 20, 1393-403
23912711   Curated Info