Ser149
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Home > Phosphorylation Site Page: > Ser149  -  CDC25B (mouse)

Site Information
FTIKRFRsLPVRLLE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7998663

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mass spectrometry (in vitro) ( 3 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
embryo ( 3 ) , oocyte ( 2 ) , RAW 264.7 (macrophage) ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKACA (mouse) ( 2 , 3 )
Kinases, in vitro:
PKACA (human) ( 3 )

Downstream Regulation
Effects of modification on CDC25B:
intracellular localization ( 3 )
Effects of modification on biological processes:
cell cycle regulation ( 2 , 3 )

References 

1

Pinto SM, et al. (2015) Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532-44
25367039   Curated Info

2

Xiao JY, Liu C, Sun XH, Yu BZ (2012) [PKA-regulated phosphorylation status of S149 and S321 sites of CDC25B inhibits mitosis of fertilized mouse eggs]. Sheng Li Xue Bao 64, 33-40
22348958   Curated Info

3

Xiao J, et al. (2011) Ser149 is another potential PKA phosphorylation target of Cdc25B in G2/M transition of fertilized mouse eggs. J Biol Chem 286, 10356-66
21212267   Curated Info