Tyr793
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Home > Phosphorylation Site Page: > Tyr793  -  FLT3 (human)

Site Information
EDLLCFAyQVAKGME   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7996202

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
leukemia ( 2 ) , acute myelogenous leukemia ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
FL ( 2 )

Downstream Regulation
Effects of modification on FLT3:
molecular association, regulation ( 1 )
Induce interaction with:
GRB10 (human) ( 1 )

References 

1

Kazi JU, Rönnstrand L (2013) FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia. Mol Oncol 7, 402-18
23246379   Curated Info

2

Razumovskaya E, et al. (2009) Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation. Exp Hematol 37, 979-89
19477218   Curated Info