Ser441
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Home > Phosphorylation Site Page: > Ser441  -  WAVE1 (mouse)

Site Information
PPGIRPSsPVAVAAL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7979602

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 2 ) , 'brain, hippocampus' ( 2 ) , 'neuron, striatal'-brain ( 3 ) , brain ( 1 )

Upstream Regulation
Regulatory protein:
CCNE2 (mouse) ( 2 )
Putative upstream phosphatases:
PPP2CA (mouse) ( 3 )
Treatments:
ciclosporin ( 3 ) , cocaine ( 1 ) , colforsin ( 3 ) , MK801 ( 1 ) , NMDA ( 3 ) , okadaic_acid ( 3 ) , SCH_23390 ( 1 ) , tautomycetin ( 3 )

Downstream Regulation
Effects of modification on WAVE1:
activity, inhibited ( 3 )

References 

1

Ceglia I, et al. (2017) WAVE1 in neurons expressing the D1 dopamine receptor regulates cellular and behavioral actions of cocaine. Proc Natl Acad Sci U S A 114, 1395-1400
28115704   Curated Info

2

Odajima J, et al. (2011) Cyclin e constrains cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell 21, 655-68
21944720   Curated Info

3

Ceglia I, Kim Y, Nairn AC, Greengard P (2010) Signaling pathways controlling the phosphorylation state of WAVE1, a regulator of actin polymerization. J Neurochem 114, 182-90
20403076   Curated Info