Ser291
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Home > Phosphorylation Site Page: > Ser291  -  TFCP2 (human)

Site Information
TYVNNsPsPGFNSSH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7965107

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
PIN1 (human) ( 2 )
Kinases, in vitro:
CDK2 (human) ( 3 )
Treatments:
EGF ( 3 ) , U0126 ( 3 )

Downstream Regulation
Effects of modification on TFCP2:
activity, inhibited ( 2 , 3 ) , phosphorylation ( 3 )
Effects of modification on biological processes:
transcription, inhibited ( 2 , 3 )

References 

1

Carrier M, et al. (2016) Phosphoproteome and Transcriptome of RA-Responsive and RA-Resistant Breast Cancer Cell Lines. PLoS One 11, e0157290
27362937   Curated Info

2

Saxena UH, et al. (2010) Prolyl isomerase Pin1 regulates transcription factor LSF (TFCP2) by facilitating dephosphorylation at two serine-proline motifs. J Biol Chem 285, 31139-47
20682773   Curated Info

3

Saxena UH, et al. (2009) Phosphorylation by cyclin C/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of LSF during G1 progression. Mol Cell Biol 29, 2335-45
19237534   Curated Info