Tyr199
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Home > Phosphorylation Site Page: > Tyr199  -  IKKB (human)

Site Information
ELLEQQKyTVTVDYW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449633

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 4 , 5 ) , phospho-antibody ( 1 , 3 , 4 , 5 ) , western blotting ( 1 , 3 , 4 , 5 )
Disease tissue studied:
cervical cancer ( 3 ) , cervical squamous cell carcinoma ( 3 ) , lung cancer ( 4 , 5 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
LYN (human) ( 1 )
Putative in vivo kinases:
LYN (human) ( 1 ) , Src (human) ( 5 )
Treatments:
BAPTA-AM ( 1 ) , phorbol_ester ( 4 , 5 ) , PP2 ( 4 , 5 ) , SCF ( 1 ) , TNF ( 4 , 5 ) , U73122 ( 1 )

Downstream Regulation
Effects of modification on IKKB:
activity, induced ( 4 , 5 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, altered ( 5 )

References 

1

Drube S, et al. (2015) TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases. Oncotarget 6, 28833-50
26353931   Curated Info

2

Meyer AN, et al. (2013) Tyrosine phosphorylation allows integration of multiple signaling inputs by IKK╬▓. PLoS One 8, e84497
24386391   Curated Info

3

Barisic S, Schmidt C, Walczak H, Kulms D (2010) Tyrosine phosphatase inhibition triggers sustained canonical serine-dependent NFkappaB activation via Src-dependent blockade of PP2A. Biochem Pharmacol 80, 439-47
20450893   Curated Info

4

Huang WC, Chen JJ, Inoue H, Chen CC (2003) Tyrosine phosphorylation of I-kappa B kinase alpha/beta by protein kinase C-dependent c-Src activation is involved in TNF-alpha-induced cyclooxygenase-2 expression. J Immunol 170, 4767-75
12707358   Curated Info

5

Huang WC, Chen JJ, Chen CC (2003) c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression. J Biol Chem 278, 9944-52
12645577   Curated Info