Tyr188
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Home > Phosphorylation Site Page: > Tyr188  -  IKKB (mouse)

Site Information
sFVGTLQyLAPELLE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449632

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , macrophage ( 1 , 2 ) , monocyte ( 2 ) , osteoclast ( 2 )

Upstream Regulation
Regulatory protein:
A3GALT2 (mouse) ( 1 ) , CD1D (mouse) ( 1 )
Putative in vivo kinases:
Pyk2 (mouse) ( 1 )
Kinases, in vitro:
Pyk2 (mouse) ( 1 )
Treatments:
CpG ( 1 ) , LPS ( 1 ) , poly(I-C) ( 1 ) , RANKL ( 2 ) , siRNA ( 1 ) , TNF ( 2 )

Downstream Regulation
Effects of modification on IKKB:
enzymatic activity, induced ( 2 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
cell differentiation, induced ( 2 ) , signaling pathway regulation ( 1 )

References 

1

Liu X, et al. (2019) Glycolipid iGb3 feedback amplifies innate immune responses via CD1d reverse signaling. Cell Res 29, 42-53
30514903   Curated Info

2

Darwech I, Otero JE, Alhawagri MA, Abu-Amer Y (2010) Tyrosine phosphorylation is required for IkappaB kinase-beta (IKKbeta) activation and function in osteoclastogenesis. J Biol Chem 285, 25522-30
20534585   Curated Info