Tyr890
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Home > Phosphorylation Site Page: > Tyr890  -  DAG1 (mouse)

Site Information
PyRsPPPyVPP____   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449630

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 3 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 3 , 4 , 5 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 ) , western blotting ( 1 , 2 , 3 , 5 )
Disease tissue studied:
leukemia ( 2 ) , acute myelogenous leukemia ( 2 ) , Duchenne muscular dystrophy ( 3 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 5 ) , C2C12 (myoblast) ( 1 ) , COS (fibroblast) ( 5 ) , H-2Kb-tsA58 (myoblast) ( 3 , 4 ) , HEK293T (epithelial) ( 5 ) , HL60 (myeloid) ( 2 ) , muscle cell ( 3 ) , myoblast ( 3 ) , WBC-blood ( 2 )

Upstream Regulation
Regulatory protein:
caveolin-1 (mouse) ( 5 )
Putative in vivo kinases:
Src (human) ( 5 ) , Src iso1 (mouse) ( 4 )
Treatments:
agrin ( 5 ) , fibronectin ( 5 ) , laminin-1 ( 5 ) , PP2 ( 4 )

Downstream Regulation
Effects of modification on DAG1:
intracellular localization ( 1 , 2 , 3 , 5 ) , molecular association, regulation ( 4 ) , protein degradation ( 3 ) , receptor internalization, induced ( 1 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 3 , 4 )
Induce interaction with:
Tks5 (mouse) ( 4 )

References 

1

Gracida-Jiménez V, et al. (2017) Retrograde trafficking of β-dystroglycan from the plasma membrane to the nucleus. Sci Rep 7, 9906
28852008   Curated Info

2

Alonso-Rangel L, et al. (2017) A role for dystroglycan in the pathophysiology of acute leukemic cells. Life Sci 182, 1-9
28591567   Curated Info

3

Miller G, et al. (2012) Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse. Hum Mol Genet 21, 4508-20
22810924   Curated Info

4

Thompson O, et al. (2008) Dystroglycan, Tks5 and Src mediated assembly of podosomes in myoblasts. PLoS One 3, e3638
18982058   Curated Info

5

Sotgia F, et al. (2003) Localization of phospho-beta-dystroglycan (pY892) to an intracellular vesicular compartment in cultured cells and skeletal muscle fibers in vivo. Biochemistry 42, 7110-23
12795607   Curated Info