Thr276
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Home > Phosphorylation Site Page: > Thr276  -  SMAD4 (mouse)

Site Information
GSRTAPYtPNLPHHQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449628

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , mutation of modification site ( 1 ) , phosphoamino acid analysis ( 1 ) , phosphopeptide mapping ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ERK2 (mouse) ( 1 )
Kinases, in vitro:
ERK2 (mouse) ( 1 )
Treatments:
TGF-beta ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on SMAD4:
intracellular localization ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )

References 

1

Roelen BA, et al. (2003) Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-beta-induced nuclear accumulation. Am J Physiol Cell Physiol 285, C823-30
12801888   Curated Info