Tyr863
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Home > Phosphorylation Site Page: > Tyr863  -  FAK (chicken)

Site Information
PAGNQHIyQPVGKPD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447965

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 , 2 ) , phosphopeptide mapping ( 3 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'stem, embryonic' ( 1 ) , CE (embryonic) ( 3 ) , CEF ( 2 )

Upstream Regulation
Regulatory protein:
Src (chicken) ( 3 )
Treatments:
fibronectin ( 2 ) , vanadate ( 3 )

Downstream Regulation
Effects of modification on FAK:
activity, induced ( 3 ) , enzymatic activity, induced ( 1 ) , phosphorylation ( 1 )

References 

1

Leu TH, Maa MC (2002) Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397. Oncogene 21, 6992-7000
12370821   Curated Info

2

Datta A, Shi Q, Boettiger DE (2001) Transformation of chicken embryo fibroblasts by v-src uncouples beta1 integrin-mediated outside-in but not inside-out signaling. Mol Cell Biol 21, 7295-306
11585912   Curated Info

3

Maa MC, Leu TH (1998) Vanadate-dependent FAK activation is accomplished by the sustained FAK Tyr-576/577 phosphorylation. Biochem Biophys Res Commun 251, 344-9
9790958   Curated Info