Tyr576
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Home > Phosphorylation Site Page: > Tyr576  -  FAK (chicken)

Site Information
RyMEDSTyyKASKGK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447889

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 , 2 ) , phosphopeptide mapping ( 3 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
'stem, embryonic' ( 2 ) , 293 (epithelial) ( 1 ) , CE (embryonic) ( 3 ) , fibroblast ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Regulatory protein:
Src (chicken) ( 3 )
Treatments:
fibronectin ( 1 ) , vanadate ( 3 )

Downstream Regulation
Effects of modification on FAK:
activity, induced ( 3 ) , enzymatic activity, induced ( 2 ) , phosphorylation ( 2 )

References 

1

Bianchi M, et al. (2005) Regulation of FAK Ser-722 phosphorylation and kinase activity by GSK3 and PP1 during cell spreading and migration. Biochem J 391, 359-70
15975092   Curated Info

2

Leu TH, Maa MC (2002) Tyr-863 phosphorylation enhances focal adhesion kinase autophosphorylation at Tyr-397. Oncogene 21, 6992-7000
12370821   Curated Info

3

Maa MC, Leu TH (1998) Vanadate-dependent FAK activation is accomplished by the sustained FAK Tyr-576/577 phosphorylation. Biochem Biophys Res Commun 251, 344-9
9790958   Curated Info