Tyr861
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Home > Phosphorylation Site Page: > Tyr861  -  FAK (rat)

Site Information
PTGNQHIyQPVGKPD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447965

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 4 ) , mass spectrometry ( 5 ) , phospho-antibody ( 3 , 4 , 6 , 7 , 8 , 9 , 10 ) , western blotting ( 3 , 4 , 6 , 8 , 9 )
Relevant cell line - cell type - tissue:
'muscle, smooth'-'heart, artery' ( 3 ) , 'muscle, smooth'-thoracic aorta ( 10 ) , brain ( 5 ) , myocardium ( 7 ) , myocyte-heart ( 4 , 6 , 8 ) , RPE-J (epithelial) ( 9 )

Upstream Regulation
Regulatory protein:
SHP-2 (rat) ( 4 )
Treatments:
angiotensin_2 ( 3 ) , anti-HER2 ( 6 ) , blood pressure ( 7 ) , endothelin ( 8 ) , neuregulin ( 6 ) , phagocytic challenge ( 9 ) , PP2 ( 3 , 6 , 8 ) , PP3 ( 8 )

References 

1

Kadaré G, et al. (2015) Conformational dynamics of the focal adhesion targeting domain control specific functions of focal adhesion kinase in cells. J Biol Chem 290, 478-91
25391654   Curated Info

2

Hsieh MY, et al. (2014) The Inducible Nitric-oxide Synthase (iNOS)/Src Axis Mediates Toll-like Receptor 3 Tyrosine 759 Phosphorylation and Enhances Its Signal Transduction, Leading to Interferon-β Synthesis in Macrophages. J Biol Chem 289, 9208-20
24526685   Curated Info

3

Koshman YE, et al. (2010) FRNK inhibition of focal adhesion kinase-dependent signaling and migration in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 30, 2226-33
20705914   Curated Info

4

Marin TM, et al. (2008) Shp2 negatively regulates growth in cardiomyocytes by controlling focal adhesion kinase/Src and mTOR pathways. Circ Res 103, 813-24
18757826   Curated Info

5

Guo A (2008) CST Curation Set: 5219; Year: 2008; Biosample/Treatment: tissue, brain/ischemia; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

6

Kuramochi Y, Guo X, Sawyer DB (2006) Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes. J Mol Cell Cardiol 41, 228-35
16769082   Curated Info

7

Fonseca PM, et al. (2005) Targeting to C-terminal myosin heavy chain may explain mechanotransduction involving focal adhesion kinase in cardiac myocytes. Circ Res 96, 73-81
15576648   Curated Info

8

Heidkamp MC, et al. (2003) Activation of focal adhesion kinase by protein kinase C epsilon in neonatal rat ventricular myocytes. Am J Physiol Heart Circ Physiol 285, H1684-96
12829427   Curated Info

9

Finnemann SC (2003) Focal adhesion kinase signaling promotes phagocytosis of integrin-bound photoreceptors. EMBO J 22, 4143-54
12912913   Curated Info

10

Sundberg LJ, et al. (2003) An endogenous inhibitor of focal adhesion kinase blocks Rac1/JNK but not Ras/ERK-dependent signaling in vascular smooth muscle cells. J Biol Chem 278, 29783-91
12782622   Curated Info