Tyr407
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Home > Phosphorylation Site Page: > Tyr407  -  FAK (rat)

Site Information
IIDEEDTyTMPSTRD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447888

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 ) , phospho-antibody ( 4 , 5 ) , western blotting ( 4 )
Relevant cell line - cell type - tissue:
brain ( 2 , 3 ) , myocardium ( 5 ) , myocyte-heart ( 4 )

Upstream Regulation
Treatments:
blood pressure ( 5 ) , neuregulin ( 4 )

References 

1

Jun HJ, et al. (2012) The oncogenic lung cancer fusion kinase CD74-ROS activates a novel invasiveness pathway through E-Syt1 phosphorylation. Cancer Res 72, 3764-74
22659450   Curated Info

2

Tucker M (2009) CST Curation Set: 7237; Year: 2009; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

Tucker M (2009) CST Curation Set: 7236; Year: 2009; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

4

Kuramochi Y, Guo X, Sawyer DB (2006) Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes. J Mol Cell Cardiol 41, 228-35
16769082   Curated Info

5

Fonseca PM, et al. (2005) Targeting to C-terminal myosin heavy chain may explain mechanotransduction involving focal adhesion kinase in cardiac myocytes. Circ Res 96, 73-81
15576648   Curated Info