Tyr284
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Home > Phosphorylation Site Page: > Tyr284  -  TGFBR2 (human)

Site Information
KIFPYEEyASWKTEk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 479864

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , 4T1 (breast cell) ( 3 ) , DR26 ( 3 ) , kidney ( 1 ) , NMuMG (epithelial) ( 2 )

Upstream Regulation
Regulatory protein:
ITGA1 (human) ( 1 )
Putative in vivo kinases:
Src iso1 (mouse) ( 3 )
Kinases, in vitro:
Src (human) ( 3 )
Phosphatases, in vitro:
PTPN2 (human) ( 1 )
Treatments:
PP2 ( 3 ) , SU6656 ( 3 )

Downstream Regulation
Effects of modification on TGFBR2:
molecular association, regulation ( 2 , 3 )
Effects of modification on biological processes:
cell growth, altered ( 2 ) , cytoskeletal reorganization ( 2 )
Induce interaction with:
GRB2 (human) ( 2 ) , GRB2 (mouse) ( 3 ) , SHC1 (mouse) ( 3 )

References 

1

Chen X, et al. (2014) Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest 124, 3295-310
24983314   Curated Info

2

Galliher-Beckley AJ, Schiemann WP (2008) Grb2 binding to Tyr284 in TbetaR-II is essential for mammary tumor growth and metastasis stimulated by TGF-beta. Carcinogenesis 29, 244-51
18174260   Curated Info

3

Galliher AJ, Schiemann WP (2007) Src phosphorylates Tyr284 in TGF-beta type II receptor and regulates TGF-beta stimulation of p38 MAPK during breast cancer cell proliferation and invasion. Cancer Res 67, 3752-8
17440088   Curated Info