Thr415
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Home > Phosphorylation Site Page: > Thr415  -  PRLR (human)

Site Information
AGGSKCStWPLPQPS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449611

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
okadaic_acid ( 1 )

Downstream Regulation
Effects of modification on PRLR:
molecular association, regulation ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
transcription, altered ( 1 )
Induce interaction with:
14-3-3 gamma (human) ( 1 ) , 14-3-3 zeta (human) ( 1 )

References 

1

Olayioye MA, et al. (2003) Threonine 391 phosphorylation of the human prolactin receptor mediates a novel interaction with 14-3-3 proteins. J Biol Chem 278, 32929-35
12819209   Curated Info