Thr171
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.5
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Thr171  -  CPEB (mouse)

Site Information
VRGSRLDtRPILDSR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449610

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , microscopy-colocalization with upstream kinase ( 4 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 4 ) , western blotting ( 1 , 2 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
'neuron, hippocampal' ( 1 ) , 293 (epithelial) ( 1 ) , COS (fibroblast) ( 2 ) , Neuro-2a (neuron) ( 1 ) , neuron-'brain, cerebellum' [transgenic] ( 2 ) , oocyte [CPEB (mouse)] ( 4 )

Upstream Regulation
Regulatory protein:
APPL (mouse) ( 3 )
Putative in vivo kinases:
AurA (mouse) ( 4 )
Kinases, in vitro:
AurA (human) ( 3 ) , AurA (mouse) ( 4 )
Putative upstream phosphatases:
PPP1CA (mouse) ( 4 )
Phosphatases, in vitro:
PPP1CA (mouse) ( 4 )
Treatments:
depolarization ( 1 ) , NMDA ( 1 )

Downstream Regulation
Effects of modification on CPEB:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cytoskeletal reorganization ( 2 ) , neural plasticity ( 2 ) , translation, altered ( 1 ) , translation, induced ( 2 )
Inhibit interaction with:
PARN (human) ( 1 )

References 

1

Udagawa T, et al. (2012) Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex. Mol Cell 47, 253-66
22727665   Curated Info

2

McEvoy M, et al. (2007) Cytoplasmic polyadenylation element binding protein 1-mediated mRNA translation in Purkinje neurons is required for cerebellar long-term depression and motor coordination. J Neurosci 27, 6400-11
17567800   Curated Info

3

Cao Q, Huang YS, Kan MC, Richter JD (2005) Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation. Mol Cell Biol 25, 10930-9
16314516   Curated Info

4

Tay J, Hodgman R, Sarkissian M, Richter JD (2003) Regulated CPEB phosphorylation during meiotic progression suggests a mechanism for temporal control of maternal mRNA translation. Genes Dev 17, 1457-62
12815066   Curated Info

5

Huang YS, Jung MY, Sarkissian M, Richter JD (2002) N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alpha CaMKII mRNA polyadenylation at synapses. EMBO J 21, 2139-48
11980711   Curated Info

Developed with grants from  NIH Logo and literature mining with Linguamatics  I2E Logo Creative Commons License PhosphoSite, created by Cell Signaling Technology is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License.

©2003-2024 Cell Signaling Technology, Inc.