Thr486

Site Information
RKRMssGtEECGEDR SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 7835300

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 ) , Jurkat (T lymphocyte) ( 2 )

Downstream Regulation
Effects of modification on SCN5A:	protein conformation ( 1 )

References
1	Lorenzini M, et al. (2021) Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation sites. J Gen Physiol 153 33410863 Curated Info
2	Zhou J (2009) CST Curation Set: 5901; Year: 2009; Biosample/Treatment: cell line, Jurkat/TPA; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (K/R)XpSX(K/R)Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser) PKC Substrate Antibody Cat#: 2261, PTMScan(R) Phospho-PKC Substrate Motif (K/RXpSXK/R) Immunoaffinity Beads Cat#: 1985 Curated Info

References

Lorenzini M, et al. (2021) Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation sites. J Gen Physiol 153
33410863 Curated Info

Zhou J (2009) CST Curation Set: 5901; Year: 2009; Biosample/Treatment: cell line, Jurkat/TPA; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (K/R)XpSX(K/R)Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser) PKC Substrate Antibody Cat#: 2261, PTMScan(R) Phospho-PKC Substrate Motif (K/RXpSXK/R) Immunoaffinity Beads Cat#: 1985
Curated Info