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Site Information |
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NtVQDPAsMRDVGGM SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 449609 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Kinases, in vitro: | |
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Downstream Regulation | |
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Effects of modification on KOR-1: | |
Effects of modification on biological processes: |
References | |
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Chen C, et al. (2022) Agonist-Promoted Phosphorylation and Internalization of the Kappa Opioid Receptor in Mouse Brains: Lack of Connection With Conditioned Place Aversion. Front Pharmacol 13, 835809
35652052 Curated Info |
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Chiu YT, et al. (2017) Agonist-Dependent and -Independent κ Opioid Receptor Phosphorylation: Distinct Phosphorylation Patterns and Different Cellular Outcomes. Mol Pharmacol 92, 588-600
28893975 Curated Info |
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Chen C, et al. (2016) Determination of sites of U50,488H-promoted phosphorylation of the mouse κ opioid receptor (KOPR): disconnect between KOPR phosphorylation and internalization. Biochem J 473, 497-508
26635353 Curated Info |
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Lemos JC, et al. (2012) Repeated stress dysregulates κ-opioid receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism. J Neurosci 32, 12325-36
22956823 Curated Info |
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Lemos JC, Roth CA, Chavkin C (2011) Signaling Events Initiated by Kappa Opioid Receptor Activation: Quantification and Immunocolocalization Using Phospho-Selective KOR, p38 MAPK, and K(IR) 3.1 Antibodies. Methods Mol Biol 717, 197-219
21370032 Curated Info |
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Clayton CC, Xu M, Chavkin C (2009) Tyrosine phosphorylation of Kir3 following kappa-opioid receptor activation of p38 MAPK causes heterologous desensitization. J Biol Chem 284, 31872-81
19773548 Curated Info |
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Xu M, et al. (2004) Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance. J Neurosci 24, 4576-84
15140929 Curated Info |
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McLaughlin JP, et al. (2004) Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance. J Biol Chem 279, 1810-8
14597630 Curated Info |