Ser369
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Home > Phosphorylation Site Page: > Ser369  -  KOR-1 (rat)

Site Information
NTVQDPAsMRDVGGM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449609

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , mutation of modification site ( 1 , 3 , 4 ) , phospho-antibody ( 2 , 4 )
Disease tissue studied:
pituitary cancer ( 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
dynorphin_A ( 4 ) , NBNI ( 4 ) , norBNI ( 2 ) , PD98059 ( 4 ) , staurosporine ( 4 ) , swim stress ( 2 ) , U50488 ( 4 ) , U73122 ( 4 )

Downstream Regulation
Effects of modification on KOR-1:
activity, induced ( 2 ) , phosphorylation ( 2 ) , receptor desensitization, altered ( 4 ) , receptor internalization, altered ( 4 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 , 2 )

References 

1

Schattauer SS, et al. (2019) Reactive oxygen species (ROS) generation is stimulated by κ opioid receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 mitogen-activated protein kinase (MAPK) activation. J Biol Chem 294, 16884-16896
31575661   Curated Info

2

Lemos JC, Roth CA, Chavkin C (2011) Signaling Events Initiated by Kappa Opioid Receptor Activation: Quantification and Immunocolocalization Using Phospho-Selective KOR, p38 MAPK, and K(IR) 3.1 Antibodies. Methods Mol Biol 717, 197-219
21370032   Curated Info

3

Bruchas MR, Macey TA, Lowe JD, Chavkin C (2006) Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes. J Biol Chem 281, 18081-9
16648139   Curated Info

4

McLaughlin JP, Xu M, Mackie K, Chavkin C (2003) Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization. J Biol Chem 278, 34631-40
12815037   Curated Info