Ser105
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Home > Phosphorylation Site Page: > Ser105  -  GATA4 (rat)

Site Information
AYTPPPVsPRFSFPG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449604

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 , 7 , 8 , 9 ) , peptide sequencing ( 9 ) , phospho-antibody ( 3 , 4 , 5 , 6 , 7 , 8 , 9 ) , western blotting ( 2 , 3 , 4 , 5 , 6 , 7 , 8 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) ( 2 ) , cardiac ( 6 ) , COS (fibroblast) ( 9 ) , granulosa ( 7 ) , H9c2 (myoblast) ( 4 , 5 ) , heart ( 5 ) , myocyte-heart ( 3 , 4 , 5 , 8 , 9 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 4 ) , ERK2 (human) ( 4 )
Kinases, in vitro:
ERK2 (rat) ( 9 )
Treatments:
angiotensin ( 9 ) , ANP ( 6 ) , endothelin ( 6 , 9 ) , glucose ( 5 ) , H-89 ( 7 ) , IGF-1 ( 3 ) , insulin ( 5 ) , isoproterenol ( 9 ) , LY294002 ( 7 ) , mannitol ( 5 ) , PD98059 ( 5 ) , phenylephrine ( 3 , 4 , 9 ) , phlorizin ( 5 ) , SB203580 ( 4 , 5 ) , serum ( 9 ) , streptozotocin ( 5 ) , tiron ( 5 ) , U0126 ( 6 , 7 , 9 ) , urofollitropin ( 7 )

Downstream Regulation
Effects of modification on GATA4:
activity, induced ( 8 , 9 ) , intracellular localization ( 3 , 5 ) , molecular association, regulation ( 3 ) , phosphorylation ( 4 )
Effects of modification on biological processes:
apoptosis, inhibited ( 2 , 8 ) , cell growth, induced ( 4 ) , signaling pathway regulation ( 3 ) , transcription, altered ( 8 ) , transcription, induced ( 2 , 5 , 6 , 7 , 9 )
Induce interaction with:
DNA ( 3 , 8 )

Disease / Diagnostics Relevance
Relevant diseases:
hypertrophic cardiomyopathy ( 4 )

References 

1

Jurado Acosta A, et al. (2020) Phosphorylation of GATA4 at serine-105 is required for left ventricular remodelling process in angiotensin-II - induced hypertension in rats. Basic Clin Pharmacol Toxicol
32060996   Curated Info

2

Gallagher JM, et al. (2012) Dissociation of Cardiogenic and Postnatal Myocardial Activities of GATA4. Mol Cell Biol 32, 2214-23
22473995   Curated Info

3

Bisping E, et al. (2012) Transcription factor GATA4 is activated but not required for insulin-like growth factor 1 (IGF1)-induced cardiac hypertrophy. J Biol Chem 287, 9827-34
22228770   Curated Info

4

Li T, et al. (2012) Involvement of ERK-RSK cascade in phenylephrine-induced phosphorylation of GATA4. Biochim Biophys Acta 1823, 582-92
22227582   Curated Info

5

Ku PM, et al. (2011) Molecular role of GATA binding protein 4 (GATA-4) in hyperglycemia-induced reduction of cardiac contractility. Cardiovasc Diabetol 10, 57
21702924   Curated Info

6

Glenn DJ, et al. (2009) Atrial natriuretic peptide suppresses endothelin gene expression and proliferation in cardiac fibroblasts through a GATA4-dependent mechanism. Cardiovasc Res 84, 209-17
19546173   Curated Info

7

Kwintkiewicz J, Cai Z, Stocco C (2007) Follicle-stimulating hormone-induced activation of Gata4 contributes in the up-regulation of Cyp19 expression in rat granulosa cells. Mol Endocrinol 21, 933-47
17227882   Curated Info

8

Kitta K, et al. (2003) Hepatocyte growth factor induces GATA-4 phosphorylation and cell survival in cardiac muscle cells. J Biol Chem 278, 4705-12
12468531   Curated Info

9

Liang Q, et al. (2001) The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes. Mol Cell Biol 21, 7460-9
11585926   Curated Info