Ser474
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Home > Phosphorylation Site Page: > Ser474  -  Akt2 (rat)

Site Information
RTHFPQFsYSASIRE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448520

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , phospho-antibody ( 1 , 3 , 4 ) , western blotting ( 1 , 3 , 4 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 1 ) , adipocyte ( 3 ) , myocardium ( 4 )

Upstream Regulation
Treatments:
adrenalectomy ( 4 ) , bradykinin ( 3 ) , calorie_restriction ( 1 ) , insulin ( 1 , 3 , 4 ) , metoprolol ( 4 ) , MK-2206 ( 1 )

References 

1

Wang H, Arias EB, Cartee GD (2016) Calorie restriction leads to greater Akt2 activity and glucose uptake by insulin-stimulated skeletal muscle from old rats. Am J Physiol Regul Integr Comp Physiol 310, R449-58
26739650   Curated Info

2

Sharma N, Arias EB, Sequea DA, Cartee GD (2012) Preventing the calorie restriction-induced increase in insulin-stimulated Akt2 phosphorylation eliminates calorie restriction's effect on glucose uptake in skeletal muscle. Biochim Biophys Acta 1822, 1735-40
22846604   Curated Info

3

Beard KM, Lu H, Ho K, Fantus IG (2006) Bradykinin augments insulin-stimulated glucose transport in rat adipocytes via endothelial nitric oxide synthase-mediated inhibition of Jun NH2-terminal kinase. Diabetes 55, 2678-87
17003331   Curated Info

4

Samuelsson AM, et al. (2006) Hyperinsulinemia: effect on cardiac mass/function, angiotensin II receptor expression, and insulin signaling pathways. Am J Physiol Heart Circ Physiol 291, H787-96
16565309   Curated Info