Ser100
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Home > Phosphorylation Site Page: > Ser100  -  BIM (mouse)

Site Information
FSFDTDRsPAPMsCD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 449602

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ERK1 (mouse) ( 2 ) , ERK2 (mouse) ( 2 ) , JNK1 (human) ( 1 )
Treatments:
gliotoxin ( 1 ) , IL-3 ( 2 ) , LY294002 ( 2 ) , PD98059 ( 2 ) , SB203580 ( 2 ) , siRNA ( 1 ) , SP600125 ( 1 , 2 ) , U0126 ( 2 )

Downstream Regulation
Effects of modification on BIM:
molecular association, regulation ( 1 , 2 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
apoptosis, altered ( 2 ) , apoptosis, induced ( 1 )
Induce interaction with:
Bcl-2 (human) ( 1 ) , Bcl-xL (human) ( 1 )
Inhibit interaction with:
BAX (mouse) ( 2 )

References 

1

Geissler A, et al. (2013) Apoptosis induced by the fungal pathogen gliotoxin requires a triple phosphorylation of Bim by JNK. Cell Death Differ 20, 1317-29
23832115   Curated Info

2

Harada H, Quearry B, Ruiz-Vela A, Korsmeyer SJ (2004) Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. Proc Natl Acad Sci U S A 101, 15313-7
15486085   Curated Info