Lys68
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Home > Acetylation Site Page: > Lys68  -  CCNA2 (human)

Site Information
LAQQQRPkTRRVAPL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 7761213

In vivo Characterization
Methods used to characterize site in vivo:
3H acetate labeling ( 2 ) , immunoassay ( 1 ) , immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , western blotting ( 1 , 2 )
Disease tissue studied:
colorectal cancer ( 2 ) , colorectal carcinoma ( 2 )
Relevant cell line - cell type - tissue:
HCT116 (intestinal) ( 2 ) , HeLa (cervical) ( 1 , 2 )

Upstream Regulation
Treatments:
siRNA ( 1 , 2 )

Downstream Regulation
Effects of modification on CCNA2:
molecular association, regulation ( 2 ) , protein degradation ( 1 , 2 )
Effects of modification on biological processes:
cell cycle regulation ( 1 , 2 )
Inhibit interaction with:
CDK2 (human) ( 2 )

References 

1

Vidal-Laliena M, et al. (2013) Histone deacetylase 3 regulates cyclin A stability. J Biol Chem 288, 21096-104
23760262   Curated Info

2

Mateo F, et al. (2009) Degradation of cyclin A is regulated by acetylation. Oncogene 28, 2654-66
19483727   Curated Info

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